Allopurinol use leading to xanthine nephrolithiasis in pediatric tumor lysis syndrome: a case series.

Autor:	Goswami, Shrea, Hanson, Amy E., Rajadhyaksha, Evan, Dangle, Pankaj P., Schwaderer, Andrew L.
Předmět:	LYMPHOBLASTIC leukemia diagnosis NEUROLOGIC examination TUMORS in children FUROSEMIDE TUMOR lysis syndrome URINARY calculi ACUTE kidney failure HEMODIALYSIS ROUTINE diagnostic tests INTRAVENOUS therapy ALLOPURINOL OXIDOREDUCTASES LYMPHOBLASTIC leukemia KIDNEYS
Zdroj:	Pediatric Nephrology; Nov2024, Vol. 39 Issue 11, p3217-3219, 3p
Abstrakt:	Tumor lysis syndrome (TLS) is a life-threatening metabolic disorder caused by massive tumor lysis. Allopurinol, a xanthine oxidase inhibitor, is initiated during chemotherapy to prevent hyperuricemia and subsequent acute kidney injury (AKI). We report two cases of xanthine nephrolithiasis during TLS in newly diagnosed hematologic malignancy patients receiving prophylactic allopurinol. Allopurinol use likely promoted xanthine crystallization, stone formation, and AKI. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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