| Abstrakt: |
Background and Aim: The purpose of this study is to determine the effect of X-ray exposure in CBCT imaging on the amount of nuclear changes and repair index of buccal mucosa cells in the patients of oral and maxillofacial radiology department of Tehran Azad University in 2022. Materials and methods: he present study is an experimental research, comparing before and after, which was conducted on 63 eligible patients. Buccal mucosa cells were examine. once before and once 10 days after X-ray exposure, Then Papanicolaou staining was used to measure the micronucleus and other nuclear changes and observation was done with a light microscope with 400× magnification. CBCT images by Papaya 3D Plus device (Genoray, Korea) with two FOVs, small (4 x 4 cm) and large (14 x 14 cm) and Voxel Size: 0.175 mm with exposure conditions of 60-90 kV and 4-12 mA were prepared. Results: Statistically significant increase in Micronucleus (p<0.001), Karyorrhexis (p<0.001), Karyolysis (p=0.01) and Broken egg (p<0.001) before and after X-ray exposure. But there is no statistically significant difference in the amount of Repair index (p=0.054) Conclusion: The present study shows that CBCT imaging can induce cytotoxic and genotoxic effects on buccal mucosa cells. Therefore, CBCT should only be prescribed when necessary because it cannot be considered a risk-free procedure. [ABSTRACT FROM AUTHOR] |
