| Abstrakt: |
Phytochemical investigation of the stems of Bridelia stipularis led to the isolation of a new triterpene, 3β-O-trans-feruloylfriedelinol (1), together with five known compounds, friedelin (2), 3β-friedelinol (3), lupeol (4), stigmasterol (5), and 4-(1,5-dimethyl-3-oxo-4-hexenyl)benzoic acid (6). Their structures were identified by intensive spectroscopic analysis including 1D and 2D nuclear magnetic resonance, infrared, and mass spectrometry. Compound 1 showed significant α-glucosidase inhibitory activity (IC50 = 337.49 ± 0.59 µM) close to the standard, acarbose. Furthermore, the structure activity relationship of 1 was analyzed by molecular docking studies. In addition, the molecular docking results showed that the interaction between 1 and the active site occurred through hydrophobic forces and hydrogen bonds. [ABSTRACT FROM AUTHOR] |
