| Abstrakt: |
A recent study conducted by researchers at the National Cancer Institute (NCI) in Bethesda, Maryland, has found that targeting SWI/SNF ATPases can reduce neuroblastoma cell plasticity. Neuroblastoma is a type of cancer that originates from neural crest cells and consists of two primary subtypes: adrenergic and mesenchymal. The researchers discovered that SWI/SNF ATPases play a crucial role in establishing a mesenchymal gene-permissive chromatin state in adrenergic-type neuroblastoma, which contributes to cellular plasticity and chemotherapy resistance. By targeting SWI/SNF ATPases, the researchers were able to inhibit neuroblastoma cell proliferation, invasion, and plasticity, suggesting that this could be an effective epigenetic target for combinational treatments in neuroblastoma. [Extracted from the article] |
