| Abstrakt: |
Researchers from Jagiellonian University Medical College have published a study on the formulation of prolonged-release minitablets with bromhexine hydrochloride (BHX) and bisoprolol fumarate (BFM) for pediatric patients. The minitablets, which have a diameter of 3 mm and a mass of 15 mg, were prepared using different grades of hydroxypropyl methylcellulose (HPMC), methylcellulose, sodium alginate, or polyvinyl alcohol (PVA) as sustained-release polymers. The study found that HPMC with a viscosity of 4000 cP and sodium alginate were effective in prolonging dissolution, while PVA was less effective. The research provides valuable insights into the development of convenient pediatric drug forms. [Extracted from the article] |
