Study Data from Case Western Reserve University Update Knowledge of Nanoparticles (Nanoparticles targeting immune checkpoint protein VISTA induce potent antitumor immunity).

Předmět:	IMMUNE checkpoint proteins REGULATORY T cells MYELOID-derived suppressor cells CYTOTOXIC T cells TECHNOLOGICAL innovations
Zdroj:	Immunotherapy Weekly; 9/17/2024, p2487-2487, 1p
Abstrakt:	A recent study conducted by researchers at Case Western Reserve University has found that nanoparticles targeting the immune checkpoint protein VISTA can induce potent antitumor immunity. The researchers developed a dual-action lipid nanoparticle (dual-LNP) that co-loaded VISTA-specific siRNA and a TLR9 agonist CpG oligonucleotide. In preclinical tumor models, the dual-LNP demonstrated superior therapeutic efficacy compared to other treatments, resulting in a high cure rate and tumor rejection. The study suggests that the dual-LNP may be a promising therapeutic platform for treating immune-cold tumors. [Extracted from the article]
Databáze:	Complementary Index
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