New Data from University of Helsinki Illuminate Research in Actinobacteria (Bioprospecting of inhibitors of EPEC virulence from metabolites of marine actinobacteria from the Arctic Sea).

Předmět:	GRAM-positive bacterial infections ANTIMICROBIAL peptides BACTERIAL metabolites GRAM-positive bacteria INTESTINAL infections ACTINOBACTERIA
Zdroj:	Health & Medicine Week; 9/20/2024, p2890-2890, 1p
Abstrakt:	A study conducted by researchers at the University of Helsinki in Finland focused on the bioprospecting of inhibitors of Enteropathogenic Escherichia coli (EPEC) virulence from metabolites of marine actinobacteria from the Arctic Sea. EPEC is a human pathogen that causes intestinal infections, particularly affecting infant mortality in developing regions. The researchers aimed to identify potential antivirulence compounds for EPEC infections among bacterial metabolites harvested from marine actinobacteria. They discovered a compound in a Kocuria strain that interferes with EPEC-induced actin polymerization without affecting growth, as well as a growth-inhibiting compound in a Rhodococcus strain. The study demonstrates the usefulness of this approach in screening for compounds capable of inhibiting EPEC virulence. [Extracted from the article]
Databáze:	Complementary Index
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