Study Findings from University of Gothenburg Update Knowledge in Alzheimer Disease (Cerebrospinal Fluid Neurofilament Light Chain and Soluble Amyloid Precursor Protein - b in the Subcortical Small Vessel Type of Dementia).

Předmět:	CENTRAL nervous system diseases ALZHEIMER'S disease TAU proteins AMYLOID beta-protein precursor RECEIVER operating characteristic curves
Zdroj:	Mental Health Weekly Digest; 9/20/2024, p646-646, 1p
Abstrakt:	A recent study conducted by researchers at the University of Gothenburg in Sweden has found that certain biomarkers in cerebrospinal fluid (CSF) can help distinguish the subcortical small vessel type of dementia (SSVD) from other forms of dementia and healthy individuals. The study focused on the CSF concentrations of neurofilament light chain (NFL) and soluble amyloid precursor protein-b (sAPP-b). Elevated NFL concentrations and decreased sAPP-b concentrations were found to independently separate SSVD from controls, and the combination of NFL and sAPP-b had a high accuracy in distinguishing SSVD from controls. Additionally, sAPP-b combined with core Alzheimer's disease biomarkers could differentiate SSVD from Alzheimer's disease and mixed dementia. These findings suggest that SSVD is a specific diagnostic entity and provide valuable insights for the diagnosis and management of dementia. [Extracted from the article]
Databáze:	Complementary Index
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