| Abstrakt: |
A recent study conducted at the Memorial Sloan-Kettering Cancer Center in New York City has found that chromosome-containing micronuclei, which are a characteristic feature of aggressive cancers, frequently undergo irreversible collapse. This collapse exposes the enclosed chromatin to the cytosol and catalyzes chromosomal rearrangements, epigenetic abnormalities, and inflammation. The study also discovered that mitochondria-derived reactive oxygen species (ROS) disrupt micronuclei by affecting the function of a protein called CHMP7, which is involved in membrane repair. This ROS-CHMP7 pathway is implicated in chromosome shattering and micronuclear disintegrity, linking tumor hypoxia with cancer progression. [Extracted from the article] |
