| Autor: |
Gohary, Yasser Mostafa, Abdelhady, Ebtehal Gamal, Sayed, Aya Nagy, Rashed, Laila Ahmed, Kamel, Hanan Abd El Razik |
| Předmět: |
|
| Zdroj: |
Beni-Suef University Journal of Basic & Applied Sciences; 9/12/2024, Vol. 13 Issue 1, p1-8, 8p |
| Abstrakt: |
Background: Vitiligo is classified as an acquired chronic depigmentation disorder that includes the destruction of epidermal melanocytes. It affects 0.5–1% of the population all over the world. Wnt signaling pathway is vital in melanocytes differentiation and development. WIF-1 is an antagonist of the Wnt signaling pathway; it hinders Wnt from binding its receptors. The present study aims to detect WIF-1 expression in vitiligo skin and if it relates to the disease's severity. Results: This case–control study included 70 subjects: 35 vitiligo patients and 35 healthy controls. Skin WIF-1 expression was estimated using quantitative real-time PCR. Assessment of the vitiligo disease activity score and vitiligo area severity index score was determined. WIF-1 expression showed significant elevation in the skin of vitiligo patients compared to the healthy control group. Conclusion: Overexpression of WIF-1 may participate in the pathogenesis of vitiligo; hence, it should be a future therapeutic target. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink