| Autor: |
Isotalus, Hanna K., Carr, Will J., Blackman, Jonathan, Averill, George G., Radtke, Oliver, Selwood, James, Williams, Rachel, Ford, Elizabeth, McCullagh, Liz, McErlane, James, O'Donnell, Cian, Durant, Claire, Bartsch, Ullrich, Jones, Matt W., Muñoz-Neira, Carlos, Wearn, Alfie R., Grogan, John P., Coulthard, Elizabeth J. |
| Předmět: |
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| Zdroj: |
Frontiers in Behavioral Neuroscience; 2024, p1-15, 15p |
| Abstrakt: |
Methods: We conducted a double-blind, randomised, placebo-controlled crossover trial with healthy older adults (65-79 years, n = 35). Participants first learned a word list and were then administered long-acting L-DOPA (or placebo) before a full night of sleep. Before sleeping, a proportion of the words were re-exposed using a recognition test to strengthen memory. L-DOPA was active during sleep and the practice-recognition test, but not during initial learning. Results: The single dose of L-DOPA increased total slow-wave sleep duration by approximately 11% compared to placebo, while also increasing spindle amplitudes around slow oscillation peaks and around 1-4 Hz NREM spectral power. However, behaviourally, L-DOPA worsened memory of words presented only once compared to re-exposed words. The coupling of spindles to slow oscillation peaks correlated with these differential effects on weaker and stronger memories. To gauge whether L-DOPA affects encoding or retrieval of information in addition to consolidation, we conducted a second experiment targeting L-DOPA only to initial encoding or retrieval and found no behavioural effects. Discussion: Our results demonstrate that L-DOPA augments slow wave sleep in elderly, perhaps tuning coordinated network activity and impacting the selection of information for long-term storage. The pharmaceutical modification of slowwave sleep and long-term memory may have clinical implications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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