Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties.

Autor: Curfs, Daniëlle M. J., Knaapen, Ad M., Pachen, Daniëlle M. F. A., Gijbels, Marion J. J., Lutgens, Esther, Smook, Marjan L. F., Kockx, Mark M., Daemen, Mat J. A. P., Van Schooten, Frederik J.
Předmět:
Zdroj: FASEB Journal; Aug2005, Vol. 19 Issue 10, p1290-1292, 3p, 1 Diagram, 1 Graph
Abstrakt: Presents a study on the role of polycyclic aromatic hydrocarbon-DNA adduct formation in atherosclerosis in apolipoprotein E knockout mice (apoE-KO). Effects of chronic benzo[a]pyrene and benzo[e]pyrene exposure on number, location and size of atherosclerotic plaques in the aortic arch of apoE-KO; Significance of macrophage-specific up-regulation of TGFβ in vivo; Analysis of the blood of the mice on plasma lipid levels and circulating inflammatory cells.
Databáze: Complementary Index