| Abstrakt: |
A facile synthetic protocol was employed to synthesize new coumarin Schiff base (E)-3-(1-((2-hydroxy-5-methylphenyl)imino)ethyl)-2H-chromen-2-one] and their Co and Cu metal complexes. Synthesized molecules were characterized by various spectroscopic methods. The results of antibacterial studies demonstrated that the maximum level of growth inhibition for S. aureus and B. subtilis was shown by compound 5, with inhibition zones of 16±1 mm and 18.5±1.3 mm, respectively, while, Compound 4 exhibited 12.5±0.5 mm and 14±0.25 mm, respectively. Invitro Cytotoxicity of Cu-complex 5 towards human hepatocellular adenocarcinoma cancer cells, at concentrations of 12.5, 25, 50, and 100 g/mL, displayed a reduction in the percentage of cell viability in a dose-dependent manner, with values of 72.45%, 60.12%, 48.69%, and 23.25%, respectively. The results revealed that Compound 5 has the potential to interact with the bacterial membrane surface, leading to the disruption of the same. Additionally, potentiometric analysis was used to estimate the proton-ligand dissociation constant of HL as well as its metal stability constants with Co2+ and Cu2+. [ABSTRACT FROM AUTHOR] |
