| Autor: |
MIGUEL, Landry Martial, AKASSA, Herman, MBOUNGOU MALONGA, Archange Emmanuel, SAMBA, Anne-Loïs NKANGA, BAHAMBOULA, Destin MBEMBA, DOBHAT-DOUKAKINI, Choupette Ravelle, NJILO TCHATCHOUANG, Didier Gesril, LEKANA, Childérick, MOUKASSA, Donatien, ABENA, Ange Antoine |
| Předmět: |
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| Zdroj: |
Journal of Drug Delivery & Therapeutics; Aug2024, Vol. 14 Issue 8, p5-9, 5p |
| Abstrakt: |
Drug iatrogenicity is a constantly evolving phenomenon, affecting several therapeutic classes. The aim of the present study was to investigate the effects of prolonged administration of oxycodone hydrochloride, a central analgesic, on reproductive functions in male rats. Materials and methods: three groups of 5 rats each were created; distilled water 0.5 ml/100g, oxycodone hydrochloride 5 and 10 mg/kg. The different products were administered orally daily for 30 days. The variables studied were: animal behaviour, prostate, testicular and epididymal weights, spermogram parameters and hormonal biomarkers (FSH, LH and testosterone levels). Results: behaviorally and morphologically, the results obtained show that oxycodone hydrochloride at doses of 5 and 10 mg/kg causes stiffness of the animals' tails, priaprism and atrophy of the prostate, testicles and epididymis, of which intensity was dose-dependent. On spermogram parameters, oxycodone hydrochloride caused a significant decrease in sperm motility (p<0.001) and in the number of normal spermatozoa (p<0.05). Administration of oxycodone hydrochloride to rats significantly decreased testosterone levels (p<0.05) and an increase in LH levels. Conclusion: Oxycodone hydrochloride, administered to animals at doses of 5 and 10 mg/kg, causes morphological disturbances of the gonads and related structures, spermogram parameters and gonadal hormones. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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