| Abstrakt: |
Introduction Hypothyroidism is a clinical syndrome resulting from deficiency of thyroid hormone leading to generalised slowing down of metabolic process. The thyroid gland, located anterior to the trachea between the cricoid cartilage and the suprasternal notch, plays a pivotal role in maintaining thermogenic and metabolic homeostasis in adults by producing thyroxine (T4) and triiodothyronine (T3) hormones. Hypothyroidism is associated with reduced Glomerular Filtration Rate (GFR), increased serum creatinine, and alterations in water excretion. Haemodynamic changes in hypothyroidism contribute to elevated serum creatinine levels. Material and Methods This is a Case control study was conducted in the Department of Biochemistry at Rangaraya Medical College, Kakinada. 50 newly diagnosed hypothyroid patients attending department of General surgery were involved. Demographic information of cases and controls are noted in data collection Tables. BMI Is calculated. Sample collection: Study participants are advised to be on overnight fast and blood sample is collected in morning in labelled red top vacutainer for T3,T4,TSH. Results The mean level in cases (1.19 ng/mL) is higher compared to controls (0.73 ng/mL). The standard deviation in cases is also higher, indicating greater variability in T3 levels among cases. The mean level in cases (6.36 µg/dL) is significantly higher compared to controls (0.64 µg/dL), with a much larger standard deviation in cases. The mean TSH level in cases (33.92 µIU/mL) is considerably higher than in controls (1.77 µIU/mL). The standard deviation in cases is also larger, suggesting greater variability. The mean uric acid level in cases (6.28 mg/dL) is higher compared to controls (5.65 mg/dL). The standard deviation is slightly lower in cases (1.32) than in controls (1.55), suggesting that while cases have a higher average uric acid level, the variability among controls is somewhat greater. The mean creatinine level in cases (0.95 mg/dL) is higher compared to controls (0.58 mg/dL). The standard deviation is also higher in cases (0.27) compared to controls (0.24), indicating that creatinine levels vary more among cases. The mean eGFR level in cases (80.26 mL/min/1.73 m²) is lower compared to controls (92.78 mL/min/1.73 m²). The standard deviation is higher in cases (15.56) compared to controls (12.18), indicating greater variability in eGFR among cases. Conclusion Present study shows that there is increased uric acid levels and creatinine levels and decreased eGFR levels in study group as compared to control group. The prevalence of hyperuricemia is high in hypothyroidism. These changes in the biochemical values is because of the renal dysfunction evident by decrease in mean eGFR level as compared to mean eGFR level in control group. Thus, these findings are helpful in understanding the interaction between thyroid gland and kidney showing the detrimental effect of hypothyroid state on renal functioning. [ABSTRACT FROM AUTHOR] |
