| Abstrakt: |
Aim: The aim of the present study was to evaluate relationship between serum vitamin D and insulin resistance in prediabetes. Methods: The current observational study was carried out at the General Medicine department for a duration of 9 months. A total of 100 people with diabetes, 96 persons with pre-diabetes, and 70 healthy control individuals were included in the sample. The inclusion criteria used consisted of individuals between the ages of 40 and 75, of either gender, who had persistent impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) throughout two oral glucose tolerance tests (OGTTs). Results: Maximum pre-diabetes (30) had serum 25 (OH) D >30 ng/ml, diabetes (32) 21-30, and control (26) >30. In diabetes, pre-diabetes, and control subjects, BMI was 25.4 kg/m2, 26.1 kg/m2, and 24.8 kg/m2, waist circumference was 92.6 cm, 89.4 cm, and 87.6 cm, waist-height ratio was 0.86, 0.54, and 0.53, waist-hip ratio was 0.96, 0.91, and 0.87, LDL-C was 98.3 mg/dl, 107.2 mg/dl, and 97.9 mg/dl, HDL-C was 45.1 mg/dl, 47.6 mg/dl, and 48.5 mg HbA1C levels were 7.6%, 6.4%, and 5.4%, with HOMA2-IR values of 2.54, 1.50, and 0.80, HOMA2-β values of 61.5, 82.2, and 84.5, and 25 (OH) D levels of 26.5, 23.1, and 21.7 ng/ml. A substantial difference was found (P<0.05). Both 1 hour and 2 hours PG blood glucose showed a strong positive connection with FBS (P< 0.05). Conclusion: Understanding the connection between vitamin D and diabetes is crucial. Insufficient levels of Vitamin-D exacerbated insulin resistance in persons diagnosed with prediabetes. [ABSTRACT FROM AUTHOR] |
