| Autor: |
Pinto, Jostol, D. S., Maitreyee, A. R., Shivashankara, Shrestha, Rashmita, Gita |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2024, Vol. 15 Issue 8, p186-192, 7p |
| Abstrakt: |
Aim: To analyze the blood levels of cardiac enzymes and urinary and serum levels of human heart-type fatty acid-binding protein (HH-FABP) in patients with ST-elevation myocardial infarction (STEMI); to analyze and assess the correlation of urinary protein HH-FABP with the blood levels of troponin I and creatine kinase (CK-MB) in patients with STEMI and to assess the correlation between serum and urine levels of HH-FABP in patients with STEMI Background: STEMI is one of several medical challenges. There is still lack of highly sensitive and specific cardiac markers for early detection of AMI and scope to develop. In this study the diagnostic yield of Human Heart type fatty acid binding protein (HH-FABP), an emerging biomarker was assessed in patients with STEMI in both serum and urine and correlated its diagnostic efficacy was correlated with other conventional markers (Troponin I and CKMB) Methods: Cross-sectional observational study. 41 patients with STEMI were studied. Serum and urine samples were collected within seven hours of onset of symptoms. HH-FABP was quantified using Enzyme Linked Immunosorbent Assay (ELISA) reader of Bio-Rad and the test result was correlated with data of Troponin I and CKMB collected from Laboratory information system (LIS). Results: Our investigation highlighted the link between plasma Troponin I and serum CKMB. However, there was no statistically significant correlation between serum and urine HH-FABP and with other markers. Conclusion: Plasma troponin I and CKMB were found to be consistently elevated in patient with STEMI. A significant correlation between serum and urine HH-FABP and other identified cardiac biomarkers was not found. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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