| Abstrakt: |
After Alzheimer's disease, Parkinson's disease (PD) is the second biggest aging-related condition worldwide. Dementia, cognitive impairment, and motor impairment are the results of a gradual degeneration of neurons that produce dopamine in the substantia nigra pars compacta and other areas of the brain. The sole goals of current therapeutic approaches, such L-dopa medication, are to reduce symptoms and slow the disease's development. Since PD currently has no known treatment, prevention is more crucial than ever. Numerous significant risk factors have been identified by more than ten years of research, including mitochondrial dysfunction and oxidative stress. The majority of current pharmaceutical treatments for Parkinson's disease (PD), the most prevalent neurological movement disorder in the world, focus on symptom relief and are frequently accompanied with unfavorable side effects during extended use. In spite of this, they continue to be the primary PD treatment because there aren't any better options. Many natural remedies derived from fruits, vegetables, and medicinal plants can be used to treat Parkinson's disease (PD). Apart from their widely recognized anti-oxidative and anti-inflammatory properties, these organic compounds also function as inhibitors in processes related to iron accumulation, protein misfolding, proteasomal breakdown maintenance, mitochondrial homeostasis, and various other neuroprotective mechanisms. The development of nutraceuticals— compounds obtained from whole food sources with potential therapeutic uses—has made it possible to employ several approaches to treat neurodegenerative illnesses like Parkinson's disease. Notably, because nutraceuticals are naturally produced chemicals and may thus have less adverse effects, they are able to market themselves as a "safer" approach. We will examine a few of the significant efforts that have been made to better understand the function of nutraceuticals in Parkinson's disease (PD) in this review. In general, these substances work by modifying signaling pathways, preventing oxidative stress, inflammation, and apoptosis, and controlling mitochondrial homoeostasis. Crucially, we will describe how the active ingredient in green tea, epigallocatechin-3-gallate, activates AMP kinase to give neuroprotection in Parkinson's disease (PD) and explain how its positive effects may be attributed to improving mitochondrial excellence of quality. [ABSTRACT FROM AUTHOR] |
