| Autor: |
Rishabh, Parakh, MukeshKumar, Sarna, Komal, Parekh, Chitresh, Kumar, Puneet, Rijhwani, Sudha, Sarna, Suchita, Verma, Shubham, Sharma, Saurabh, Soopa |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2024, Vol. 15 Issue 7, p2264-2268, 5p |
| Abstrakt: |
Background- Sepsis is a severe, life-threatening condition resulting from an abnormal and uncontrolled immune response to infection, posing a significant global health challenge. Blood coagulation disorders are significant complications in sepsis, often exacerbating the severity of the condition. The APACHE II (Acute Physiology and Chronic Health Evaluation II) score is a widely used severity-of-disease classification system that provides valuable prognostic information in critically ill patients. This study aims to investigate the relationship between various blood coagulation parameters and the severity of sepsis as assessed by the APACHE II score. Materials And Methods- A descriptive cross-sectional hospital-based study was conducted in the Department of General Medicine at Mahatma Gandhi Medical College & Hospital, Jaipur, on patients admitted to the ICU diagnosed with sepsis according to Sepsis-3 criteria. Blood coagulation parameters, including platelet count, PT, aPTT, D-dimer, and fibrinogen levels, were monitored and compared to assess the severity of sepsis using the APACHE II score. Results- The study included 168 sepsis patients aged 18 to 65 years. The mean APACHE II score was 29.08, with a significant correlation between age and APACHE II scores (p<0.001). The study found 68.5% of patients in a hypo-coagulation state and 31.5% in a hyper-coagulation state. Significant correlations were observed between APACHE II scores and PT, aPTT, D-dimer, and platelet count. Conclusions- The study highlights the critical role of blood coagulation disorders in the pathophysiology of sepsis and their correlation with disease severity as assessed by the APACHE II score. Routine monitoring of coagulation parameters in sepsis patients is essential, and incorporating these parameters into the APACHE II scoring system could provide a more comprehensive assessment of sepsis severity, aiding in better prognostication and treatment planning. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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