| Autor: |
Bi, De-Wen, Feng, Jian-, Pang, Wen-Hui, Yang, Peng-Yun, Xu, Yao-Jun, Aurang Zeb, Muhammad, Wang, Meng-Ru, Zhang, Xing-Jie, Li, Xiao-Li, Zhang, Rui-Han, Wang, Wei-Guang, Xiao, Wei-Lie |
| Předmět: |
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| Zdroj: |
Natural Product Research; Sep2024, Vol. 38 Issue 17, p3041-3050, 10p |
| Abstrakt: |
Three new lanostane triterpenoids (1-3) along with two new amides fatty compounds (4-5) were isolated from the ethyl acetate extract of a culture of the endophytic fungus Alternaria sp. gx-2. Their structures were identified by 1D and 2D NMR spectral data and HRESIMS. Compounds 1-12 were evaluated for their anti-inflammatory and tyrosinase inhibition activities. The isolated compounds did not show inhibitory activities at a concentration of 100 μM against tyrosinase, while under the concentration of 10 μM, the release of lactate dehydrogenase (LDH) inhibition rate of compound 1 was 54.45%, indicating that compound 1 had moderate anti-inflammatory activity on the activation of NLRP3 inflammasome. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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