| Autor: |
Ni, Fuyong, Xie, Xue, Huai, Xue, Yu, Xiao, Zhang, Hongda, Li, Ming, Wen, Jianhui, Yan, Ming, Zhang, Chenfeng, Wang, Zhenzhong, Xiao, Wei |
| Předmět: |
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| Zdroj: |
Natural Product Research; Sep2024, Vol. 38 Issue 17, p2927-2933, 7p |
| Abstrakt: |
Three undescribed coumarins, 6-(3-hydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin (1), (R)-6-(1,3-dihydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin (2), angelol N (6), together with four known coumarins were isolated from the roots of Angelica pubescens. Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compounds 2 and 6 were assigned via electronic circular dichroism (ECD). Their inhibitory effects on lipopoly-saccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Compounds 1–4 exhibited moderate inhibitory activities. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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