| Autor: |
Tian, Jin-Rui, Qiao, Yu-Hao, Zhuang, Qing-Bo, Fan, Rong, Li, Zhen, Zhang, Xiao-Ming, Zhang, Fu-Min, Tu, Yong-Qiang |
| Předmět: |
|
| Zdroj: |
Chemical Communications; 9/18/2024, Vol. 60 Issue 73, p9954-9957, 4p |
| Abstrakt: |
A catalytic asymmetric α-hydroxylation of pyridinone-fused lactones, containing the core structure of camptothecin, is described. Development of a novel spiropyrrolidine amide (SPA) derived triazolium bromide organo-cation catalyst is crucial for a highly enantioselective oxidation, which also accommodates a wide array of lactones with various substituents. The resulting tricyclic tertiary alcohol with an oxa-quaternary carbon center can be further applied in the synthesis of SN-38 and irinotecan, two anti-cancer drugs derived from camptothecin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
