| Abstrakt: |
Objective: Based on network meta-analysis, the efficacy of different Chinese herbal decoction in the treatment of adult severe pneumonia was evaluated. Methods: Computer search of CNKI, VIP, Wangfang, Cochrane Library, Embase, PubMed, Web of science databases. randomized controlled trials (RCT) on TCM decoction for severe pneumonia in adults were collected up to July 31, 2023. The Cochrane bias risk assessment tool was used to assess the quality of the included literature, and Stata17.0 software was used to perform a network meta-analysis based on the frequency framework. Results: Finally, 40 RCTs were included, involving 13 traditional Chinese medicines and 3 773 patients. The results of network meta-analysis showed that Maxingshigan Decoction combined with QianjinWeijian Decoction + Western medicine routine may be the most effective intervention in improving clinical efficacy, QingfeiTongfu Decoction + Western medicine routine may be the most effective in improving CRP, QingjinHuatan decoction + Western medicine routine may be the most effective in improving IL-6 and TNF-α. Maxingshigan Decoction + Western medicine routine may be the most effective in improving PCT, Xuanbai Chengqi decoction + Western medicine routine may be the most effective in improving APACHE II and CPIS. Conclusion: The curative effect of TCM decoction combined with conventional western medicine on adult severe pneumonia is better than that of conventional Western medicine and the adverse reaction is less. However, limited by the quality and number of included literatures, the above conclusions still need to be further verified. [ABSTRACT FROM AUTHOR] |
