Chemosensory assessment and impact on quality of life in neurosensorial cluster of the post COVID 19 syndrome.

Autor: Gentilotti, Elisa, Gorska, Anna, Cecchini, Maria Paola, Mirandola, Massimo, Meroi, Marco, De Nardo, Pasquale, Sartori, Andrea, De Toffoli, Chiara Konishi, Kumar-Singh, Samir, Zanusso, Gianluigi, Monaco, Salvatore, Tacconelli, Evelina, Guedes, Mariana Nunes Pinho, Maccarrone, Gaia, Canziani, Lorenzo Maria, Davies, Ruth Joanna, Vitali, Stefania, Tomassini, Giorgia, Barana, Benedetta, Pezzani, Maria Diletta
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Zdroj: Scientific Reports; 9/9/2024, Vol. 14 Issue 1, p1-14, 14p
Abstrakt: COVID-19 pandemic brought chemosensory impairment to the forefront of medicine, revealing gaps in the knowledge of pathophysiological mechanisms, true prevalence and preventive/therapeutic alternatives. This is a sub-study of the ORCHESTRA cohort focusing on post-COVID-19 chemosensory symptoms. Risk factors for neurosensorial cluster of post-COVID-19 syndrome (NSc-PCS) were assessed through multivariable analysis. Psychophysical validated tests were applied on a sub-population of 50 patients. Qualitative chemosensory symptoms as well as nasal and oral chemesthesis were evaluated through anamnestic interview and the quality of life through the SF-36 questionnaire. Chemosensory symptoms evolution and olfactory training's outcome were assessed through phone-call interviews. Out of 1187 patients (female, N = 630), 550 (47%) presented NSc-PCS, with a lower risk for older age and monoclonal antibodies treatment, and a higher risk in females (p < 0.001). Out of the 50 patients evaluated with psychophysical tests, 66% showed smell reduction with a qualitative alteration in 50% of hyposmic and 35% of normosmic patients. Hypogeusia was present in 14 (28%) of the patients assessed, with 56% showing a qualitative alteration; 53% of normogeusic patients presented qualitative disorders. NSc-PCS has a complex, fluctuating, multifaceted presentation. Quantifying and characterizing COVID-19-related chemosensory impairment is key to understand underlying mechanisms and to develop preventive and therapeutic treatment. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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