Effect of Mimosa Himalayana Extract on Potassium Oxonate Induced Hyperuricemia in Rats.

Autor: Shaheen, Bushra, Fatima, Javaria, Qammar, Sheikh Maria, Malik, Tooba, Batool, Saba, Noureen, Saima
Předmět:
Zdroj: Pakistan Armed Forces Medical Journal; Aug2024, Vol. 74 Issue 4, p984-984, 1p
Abstrakt: Objective: To determine the hypouricemic effect of Mimosa himalayana extract on potassium oxonate induced hyperuricemia in rats. Study Design: Laboratory-based Experimental study. Place and Duration of Study: Pharmacology Department, University of Health Sciences Lahore Pakistan, from Jan 2017 to Dec 2018. Methodology: Forty-eight healthy male Wistar rats were placed randomly in 6 Groups (n=8). Group-I served as negative control while hyperuricemia was induced in Groups II, III, IV, V and VI with potassium oxonate 250 mg/kg intraperitoneally on day 1st, 3rd and 7th. Group-II served as positive control while Group III received allopurinol 5 mg/kg body weight orally once daily for seven days. Groups IV, V and VI were treated with Mimosa himalayana extract 100, 200 and 400 mg/kg body weight by gavage once daily for 7 days respectively. Oral acute toxicity was observed in eighteen rats for three days with a dose of 1000 and 2000 mg/kg body weight. On day seven, all animals were sacrificed, and blood was collected for serum separation. Serum uric acid was measured with the help of chemistry analyzer. Results: Mimosa himalayana extract showed no signs of acute toxicity in rats with 1000 mg/kg and 2000 mg/kg oral dose. Hyperuricemia was successfully induced with potassium oxonate. Treatment with allopurinol (5 mg/kg) markedly reduced serum uric acid levels (p<0.05). Mimosa himalayana extract (100mg/kg, 200mg/kg and 400mg/kg) also reduced serum uric acid levels significantly (p<0.05). Conclusion: Mimosa himalayana extract possesses significant hypouricemic effect. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje