| Autor: |
Younus, Nadia, Rasheed, Aaqiba, Turab, Syed Mohsin, Ali, Asma Basharat, Mukhtar, Sahrish, Jamshed, Nausheen |
| Předmět: |
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| Zdroj: |
Annals of Abbasi Shaheed Hospital & Karachi Medical & Dental College; 9/30/2024, Vol. 29 Issue 3, p240-240, 1p |
| Abstrakt: |
Objective: Withania Somnifera is a naturally occurring antioxidant. This study was designed to analyze the oxidative effects of the anti-cancer drug cisplatin on rat spleen and blood parameters and its amelioration by the root extract of Withania Somnifera. Methods: This experimental study was conducted during November and December 2023 in the Anatomy departments of Islam Medical and Dental College and Jinnah Medical and Dental College, after the approval of the Institutional Animal Ethical Committee. 60 male Albino Wistar rats, 14-16 weeks old and weighing 200-250 gm were randomly divided into 4 groups. Initial body weights were taken for all groups. Group A received no treatment, group B was given an intraperitoneal injection of Cisplatin as a single daily dose for 7 days, group C received W. somnifera root extract orally for 15 days as a pretreatment and then concurrently with intraperitoneal cisplatin for 7 days and group D was given W. somnifera root extract only for 22 days. At the end of the study period, the rats were sacrificed. Final body and splenic weights were taken, blood was collected and splenic tissue was processed for histological analysis. Statistical analysis of data was done using SPSS version 25.0. Results: The rats of Cisplatin only group B showed significant toxic changes in splenic histology: thickened splenic capsule, white pulp reduction with reduced PALS areas, and central artery vacuolization. These changes were improved in cisplatin and W. somnifera group C. Blood profiles showed decreased Hb, TLC, and platelets in cisplatin only group B but it was improved in the cisplatin and W. somnifera group C. Conclusion: Our study concluded that W. somnifera root extract protects against cisplatin induced oxidative damage to splenic tissue and hematological alterations in rat model. This ponders on its potential as an adjuvant therapy with anticancer cisplatin treatment for minimizing its side effects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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