| Autor: |
Schepps, Samuel, Xu, Jonathan, Yang, Henry, Mandel, Jenna, Mehta, Jaanvi, Tolotta, Julianna, Baker, Nicole, Tekmen, Volkan, Nikbakht, Neda, Fortina, Paolo, Fuentes, Ignacia, LaFleur, Bonnie, Cho, Raymond J., South, Andrew P. |
| Předmět: |
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| Zdroj: |
Clinical Chemistry & Laboratory Medicine; Sep2024, Vol. 62 Issue 10, p1880-1891, 12p |
| Abstrakt: |
Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, prognosis, and ultimately clinical practice. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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