Simple Access to 3-(Hetero)arylated Derivatives of 2-Furoic Acid via Ru(II)-Catalyzed C3-H Arylation of 2-Furoylimidazole.

Autor: Shepelenko, Konstantin E., Gnatiuk, Irina G., Lavrentev, Igor V., Minyaev, Mikhail E., Chernyshev, Victor M., Ananikov, Valentine P.
Předmět:
Zdroj: Synthesis; Oct2024, Vol. 56 Issue 19, p3063-3073, 11p
Abstrakt: A new approach for the preparation of a variety of 3-arylated 2-furoic acid derivatives has been developed. The approach involves selective Ru-catalyzed C3-H arylation of the furan moiety of readily available 2-furoyl-1-methylimidazole (using imidazole as a removable N-donor directing group), subsequent N-methylation, and nucleophilic substitution of the imidazole moiety with N, O, S, and C nucleophiles. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index