Highly efficient synthesis of enantioenriched vicinal halohydrins via Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution.

Autor: He, Bin, Chen, Gen-Qiang, Zhang, Xumu
Předmět:
Zdroj: Chemical Communications; 9/16/2024, Vol. 60 Issue 72, p9785-9788, 4p
Abstrakt: A novel synthetic route was developed for the construction of chiral cis-vicinal halohydrins derivatives through Ir/f-phamidol-catalysed asymmetric hydrogenation of corresponding α-halogenated ketones with high yields (up to 99% yield), excellent diastereoselectivities (>20 : 1 dr), enantioselectivities (up to 99% ee), and high substrate catalyst ratio (S/C = 1000). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index