| Autor: |
Vázquez, Álvaro Aguado, Corrales, Andrea Estébanez, Ramos, F Javier Melgosa, Galy, José Manuel Mascaró, Fulgencio-Barbarin, Jon, Amate, Xavier Bosch, Barredo, Laia Curto, Blanes-Martínez, Mar, Ruiz-Villaverde, Ricardo, Martínez, Asunción Ballester, Martín-Torregrosa, Daniel, Fernández, Juan Luis Castaño, Martínez, Rita Cabeza, Pérez-Ferriols, Amparo, Rodríguez, Daniel Ramos, Vilanova, Julian Boix, Melé-Ninot, Gemma, Serrano, Vicente Expósito, Alonso, Agustin España, Mateu-Puchades, Almudena |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Dermatology; Sep2024, Vol. 49 Issue 9, p1002-1006, 5p |
| Abstrakt: |
Background Bullous pemphigoid (BP) is the most common autoimmune blistering disease. Most patients are older and have associated multiple comorbidities. Topical and systemic corticosteroids are considered the first-line treatment for BP, and immunosuppressants are used as steroid-sparing treatments. However, both have side-effects and contraindications, which are even more common in this older population. New treatments targeting interleukins and receptors related to BP pathogenesis have been proposed to decrease these side-effects while achieving equal or better effectiveness and response rates. Omalizumab is a monoclonal antibody that targets IgE and has been proposed for the treatment of BP due to the evidence that IgE autoantibodies play an essential role in BP pathogenesis. Objectives To assess the efficacy and safety of omalizumab for the treatment of BP. Methods We carried out a multicentre, retrospective, observational study including patients diagnosed with BP who received omalizumab for ≥ 3 months from 15 tertiary hospitals in Spain. IgE levels prior to treatment were measured, and we evaluated the possible correlation with clinical response. We excluded patients treated with omalizumab for < 3 months, as we consider this duration to be insufficient for a comprehensive assessment of its efficacy. To evaluate the effectiveness of the treatment, we used the percentage of body surface area improvement. Results We included 36 patients. The vast majority had associated multiple comorbidities, and all patients had used other systemic therapies apart from corticosteroids before omalizumab. In total, 83% experienced some kind of treatment response and 42% of all patients treated achieved complete response. We did not find any correlation between higher IgE levels and a better response (P = 0.2). All patients tolerated omalizumab without reported side-effects. Conclusions Omalizumab is a good therapeutic alternative for BP as it provided clinical response in most patients, and nearly one-half of the cases achieved complete response. It showed no side-effects, which is crucial in older patients with BP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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