| Abstrakt: |
Researchers from the University of Portsmouth in the United Kingdom have conducted a study on tissue engineering, specifically focusing on the muscle tendon junction (MTJ). The MTJ is a critical area where tears and strains commonly occur, but regeneration is limited due to poor vascularization and tissue complexity. The researchers fabricated aligned electrospun polycaprolactone fibers and cultured human myoblasts and tenocytes on the scaffold. They found that applying strain and co-culturing myoblasts and tenocytes significantly increased cell elongation, MTJ marker gene expression, and the production of proteins found in the MTJ. This study provides new insights into the development of a tissue-engineered MTJ, which could potentially lead to novel treatments for MTJ tears. [Extracted from the article] |
