Nottingham Trent University Reports Findings in Pain (Cisplatin induced alterations in nociceptor developmental trajectory elicits a TrkA dependent platinum-based chemotherapy induced neuropathic pain).

Předmět:	CANCER chemotherapy ALKYLATING agents DORSAL root ganglia NERVE growth factor PLATINUM compounds
Zdroj:	Pediatrics Week; 9/13/2024, p312-312, 1p
Abstrakt:	A recent study conducted by researchers at Nottingham Trent University in the United Kingdom has investigated the development of neuropathic pain in pediatric cancer survivors who have undergone cisplatin-based chemotherapy. The researchers found that cisplatin treatment led to increased TrkA expression in sensory neurons, resulting in sensory neuritogenesis and nociceptor sensitization. However, the administration of a TrkA antagonist was able to prevent cisplatin-induced neuropathic pain. These findings provide a better understanding of the mechanisms underlying this type of pain and may help identify potential therapeutic targets. [Extracted from the article]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu