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| Zdroj: |
Genomics & Genetics Weekly; 9/13/2024, p2332-2332, 1p |
| Abstrakt: |
A recent report from the University of Illinois Urbana-Champaign discusses research on the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1), which plays a role in learning and memory. The study found that Arc protein has similarities to viral Group-specific antigen (Gag) protein and facilitates intercellular RNA transfer through virus-like capsids. The researchers identified that phosphatidylinositol-3-phosphate (PI3P) mediates Arc capsid assembly and secretion through the endosomal-multivesicular body (MVB) pathway. Understanding this secretion pathway provides insights into Arc's role in intercellular cargo transfer and highlights similarities and differences between trafficking mechanisms of structurally similar capsid proteins. [Extracted from the article] |
| Databáze: |
Complementary Index |
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