The effect of niacin on inflammatory markers and adipokines: a systematic review and meta-analysis of interventional studies.

Autor:	Rad, Esmaeil Yousefi, Saboori, Somayeh, Tammam, Jonathan, Thondre, Pariyarath Sangeetha, Coe, Shelly
Předmět:	ADIPOKINES MEDICAL information storage & retrieval systems STATISTICAL models ANTI-inflammatory agents LEPTIN CONTROLLED release preparations META-analysis DESCRIPTIVE statistics SYSTEMATIC reviews MEDLINE ADIPONECTIN DOSE-effect relationship in pharmacology MEDICAL databases INFLAMMATION ONLINE information services CONFIDENCE intervals DATA analysis software DIETARY supplements NIACIN BIOMARKERS C-reactive protein INTERLEUKINS TUMOR necrosis factors PHARMACODYNAMICS
Zdroj:	European Journal of Nutrition; Sep2024, Vol. 63 Issue 6, p2011-2024, 14p
Abstrakt:	Purpose: Niacin (nicotinic acid), known for its lipid-modifying effects, has been explored for its potential anti-inflammatory properties and potential to affect adipokines secretion from adipose tissue. The aim of this systematic review and meta-analysis was to assess the effects of niacin on inflammatory markers and adipokines. Methods: A comprehensive search was conducted across five databases: PubMed, Scopus, Cochrane Library, Embase, and ISI Web of Science. Randomized controlled trials exploring the effects of niacin on inflammatory markers (CRP, IL-6, TNF-α) and adipokines (Adiponectin, Leptin) were included. Pooled effect sizes were analysed using a random-effects model, and additional procedures including subgroup analyses, sensitivity analysis and dose-response analysis were also performed. Results: From an initial 1279 articles, fifteen randomized controlled trials (RCTs) were included. Niacin administration demonstrated a notable reduction in CRP levels (SMD: -0.88, 95% CI: -1.46 to -0.30, p = 0.003). Subgroup analyses confirmed CRP reductions in trials with intervention durations ≤ 24 weeks, doses ≤ 1000 mg/day, and elevated baseline CRP levels (> 3 mg/l). The meta-analysis of IL-6 and TNF-α revealed significant TNF-α reductions, while IL-6 reduction did not reach statistical significance. Niacin administration also substantially elevated Adiponectin (SMD: 3.52, 95% CI: 0.95 to 6.1, p = 0.007) and Leptin (SMD: 1.90, 95% CI: 0.03 to 3.77, p = 0.04) levels. Conclusion: Niacin treatment is associated with significant reductions in CRP and TNF-α levels, suggesting potential anti-inflammatory effects. Additionally, niacin positively influences adipokines, increasing Adiponectin and Leptin levels. These findings provide insights for future research and clinical applications targeting inflammation and metabolic dysregulation. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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