| Abstrakt: |
This meta-analysis evaluated the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors. Data on cardiovascular biomarkers from 28 general population-based cohorts from 12 countries and 4 continents were evaluated. Overall, data were analysed for 164,054 individuals (median age 53.1 years, 52.4% female). 17,211 incident ASCVD events were reported during a median 11.8 years of follow-up. All biomarkers were significantly associated with incident ASCVD; subdistribution HRs per 1-SD change were 1.13 (95% CI 1.11-1.16) for high-sensitivity cardiac troponin I; 1.18 (95% CI 1.12-1.23) for high-sensitivity cardiac troponin T; 1.21 (95% CI 1.18-1.24) for N-terminal pro-B-type natriuretic peptide; 1.14 (95% CI 1.08-1.22) for B-type natriuretic peptide; and 1.14 (95% CI 1.12-1.16) for high-sensitivity C-reactive protein. The addition of each single biomarker to a model that included established risk factors improved the C statistic. For 10-year incident ASCVD in people aged <65 years, the combination of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and high-sensitivity C-reactive protein improved C statistic from 0.812 to 0.8194. [ABSTRACT FROM AUTHOR] |
