| Abstrakt: |
Background: Piwi-interacting RNAs (piRNAs) are a type of non-coding RNAs, initially identified in germ cells in 2006, known to bind to the Piwi family proteins. Accumulating studies indicate their importance in genome stability, epigenetics regulation, germ cell differentiation, and tumor development. Despite growing interest in piRNA research, there is a lack of comprehensive bibliometric studies on the subject. This study aims to analyze piRNA research trends from 2006 to 2023. Methods: The literature regarding piRNA was sourced from the Web of Science on April 25, 2023. VOSviewer, CiteSpace and a bibliometric online website (https://bibliometric.com/app) were employed to perform bibliometric analysis. Network maps were constructed to evaluate the collaborations among countries, institutions, authors, journals, references, keywords, and research hot pots. Results: In this study, 2549 literature were published across 464 countries and 6921 institutions, comprising 2010 articles and 539 reviews. The United States led in publication output (n = 1011, 39.66%), followed by China (635, 24.91%). The University of Tokyo had the most publications among all institutions (n = 100, 3.92%), followed by the Chinese Academy of Sciences (n = 86, 3.37%). Among 631 published journals, Nucleic Acids Research was the most published journal (n = 83, 3.26%). Siomi Mikiko C published the most articles (n = 58), with Aravin Alexei A as the most co-cited author. Analysis of term co-occurrence unveiled three highly interconnected clusters, including “piRNA biogenesis and function”, “cancer and regulation”, as well as “protein and species”. The research focus has transferred from male reproductive development to tumor progression. Conclusion: This bibliometric analysis offered a thorough overview of the current state of piRNA research, deepening understanding of the progress in this field over the last 17 years and providing a valuable reference for scholars engaged in piRNA studies. [ABSTRACT FROM AUTHOR] |
