In Vitro Sustained Human Transscleral Drug Delivery of Fluorescein-Labeled Dexamethasone and Methotrexate with Fibrin Sealant.

Autor:	J. Cruysberg, Lars P., M. A. Nuijts, Rudy M., Gilbert, Jake A., Geroski, Dayle H., Hendrikse, Fred, Edelhauser, Henry F.
Předmět:	FIBRIN tissue adhesive ADHESIVES in surgery DRUG delivery systems PHARMACEUTICAL technology METHOTREXATE AMINOBENZOIC acids SCLERA
Zdroj:	Current Eye Research; Aug2005, Vol. 30 Issue 8, p653-660, 8p
Abstrakt:	Purpose : To study the use of fibrin sealant as a drug delivery system for the sustained transscleral delivery of dexamethasone and methotrexate. Methods : Scleral sections excised from moist-chamber-stored human globes were mounted in a perfusion chamber. Dexamethasone-fluorescein or methotrexate-fluorescein in either fibrin sealant or balanced salt solution (BSS) was applied to the episcleral surface. BSS was perfused to the choroidal side, fluorescence was measured in perfusate fractions, and an apparent scleral permeability P A was calculated for each solute-vehicle combination. Results : P A for both compounds was significantly lower with fibrin sealant delivery compared to delivery in BSS (p [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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