| Autor: |
Mota Díaz, Isaac Izcoatl, Douda, Janna, García López, Patricia, Cabrera Becerra, Sandra Edith, Gómez Álvarez, Miguel Ángel, Jiménez Rodríguez, Rebeca, Jurado León, Rafael, López Sánchez, Pedro |
| Předmět: |
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| Zdroj: |
Colloids & Interfaces; Aug2024, Vol. 8 Issue 4, p42, 12p |
| Abstrakt: |
The synergistic effect of antineoplastic drug co-encapsulation systems has made them highly regarded due to their improved pharmacological efficacy. Biopolymer-coated liposomes were evaluated for paclitaxel and doxorubicin co-encapsulation in MCF-7 and MDA-MB-231 breast cancer cell lines. These nanosystems are characterized by dynamic light scattering, transmission electron microscopy, and UV–VIS spectroscopy. The conventional and hybrid liposomal systems presented sizes of 150 to 230 nm and %EE greater than 80% for the encapsulated active ingredients. These drug-laden liposomal systems significantly decreased cell viability in both breast cancer cell lines compared with liposome-free drugs. The delivery of antineoplastic drugs in breast cancer therapy could potentially benefit from new hybrids for drug co-encapsulation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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