Pathological Features Associated with Lymph Node Disease in Patients with Appendiceal Neuroendocrine Tumors.

Autor: Rodriguez Franco, Salvador, Ghaffar, Sumaya Abdul, Jin, Ying, Weiss, Reed, Hamermesh, Mona, Khomiak, Andrii, Sugawara, Toshitaka, Franklin, Oskar, Leal, Alexis D., Lieu, Christopher H., Schulick, Richard D., Del Chiaro, Marco, Ahrendt, Steven, McCarter, Martin D., Gleisner, Ana L.
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Zdroj: Cancers; Aug2024, Vol. 16 Issue 16, p2922, 10p
Abstrakt: Simple Summary: This study investigated whether certain features of appendiceal neuroendocrine tumors, beyond tumor size, can help predict the risk of lymph node invasion. We reviewed over 5000 cases from a national cancer database and found that in addition to the size of the tumor, lymphovascular invasion is a very strong risk predictor. Interestingly, we discovered that the growth of the tumor into deeper layers, which is usually considered a critical factor in evaluating small tumors, did not significantly affect the risk of lymph node invasion. This study aims to refine how we assess the risk of local spreading, encouraging a more tailored surgical approach, which could prevent unnecessary procedures and better focus on what is truly necessary for patient care. This study aimed to evaluate the role of pathological features beyond tumor size in the risk of lymph node metastasis in appendiceal neuroendocrine tumors. Analyzing data from the national cancer database, we found that among 5353 cases, 18.8% had lymph node metastasis. Focusing on tumors smaller than 2 cm, a subject of considerable debate in treatment strategies, we identified lymphovascular invasion as one of the strongest predictors of lymph node disease. Interestingly, extension into the subserosa and beyond, a current factor in the staging system, was not a strong predictor. These findings suggest that careful interpretation of pathological features is needed when selecting therapeutic approaches using current staging systems. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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