| Autor: |
Nagayama, Takashi, Fujiwara, Shin-ichiro, Tominaga, Ryutaro, Yokoyama, Daizo, Noguchi, Atsuto, Furuki, Shuka, Oyama, Takashi, Koyama, Shunsuke, Murahashi, Rui, Nakashima, Hirotomo, Ikeda, Takashi, Hyodo, Kazuki, Kawaguchi, Shin-ichiro, Toda, Yumiko, Umino, Kento, Minakata, Daisuke, Morita, Kaoru, Ashizawa, Masahiro, Yamamoto, Chihiro, Hatano, Kaoru |
| Předmět: |
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| Zdroj: |
Leukemia & Lymphoma; Sep2024, Vol. 65 Issue 9, p1350-1356, 7p |
| Abstrakt: |
The tumor microenvironment's cells can promote or inhibit tumor formation, and there are no reports on the CD4/CD8 ratio's association with outcomes post allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively evaluated the pre-transplant peripheral blood CD4/CD8 ratio in 168 patients who underwent their first allo-HSCT for hematological malignancies at our institution. When patients were divided into two groups according to the median CD4/CD8 ratio 1.35 (range, 0.09–19.89), the high CD4/CD8 ratio group had a higher incidence of relapse, equivalent non-relapse mortality and worse overall survival (OS) than the low CD4/CD8 ratio group. In a multivariate analysis, the CD4/CD8 ratio was significantly associated with an increased risk of relapse, although there was a marginally significant difference in OS. The pre-transplant peripheral blood CD4/CD8 ratio could be a novel biomarker for predicting the prognosis of allo-HSCT. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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