| Abstrakt: |
Researchers at the Chinese Academy of Medical Sciences have conducted a study on the innate immune system's response to intracellular single-stranded DNA (ssDNA). They found that ssDNA triggers cytokine expression and cell death in a CGT motif-dependent manner. The researchers identified Schlafen 11 (SLFN11) as an ssDNA-activated RNase that is essential for the immune response to ssDNA and adeno-associated virus infection. Mice deficient in Slfn9, a mouse homolog of SLFN11, showed resistance to CGT ssDNA-induced inflammation, acute hepatitis, and septic shock. This study provides insights into the immune response to ssDNA and the role of SLFN11 in triggering innate immune responses. [Extracted from the article] |
