Estimated glomerular filtration rate: applicability of creatinine-based equations in African children.

Autor: Nkoy, Agathe Bikupe, Matoka, Therance Tobo, Bukabau, Justine Busanga, Sumaili, Ernest Kiswaya, Labarque, Veerle, van den Heuvel, Lambertus P., Levtchenko, Elena, Cavalier, Etienne, Delanaye, Pierre, Ekulu, Pépé Mfutu, Pottel, Hans
Předmět:
Zdroj: Pediatric Nephrology; Oct2024, Vol. 39 Issue 10, p3013-3022, 10p
Abstrakt: Background: The Schwartz equation is the most widely used serum creatinine (SCr)-based formula to estimate the glomerular filtration rate (GFR) in children of European descent, but whether this applies to African children is unclear. Methods: In a cross-sectional study, 513 apparently healthy African children aged 6 to 16 years were randomly recruited in school area of Kinshasa, the Democratic Republic of Congo (DRC). SCr was measured using calibrated enzymatic method. SCr was normalized using Q-values designed for European descent children, due to the absence of Q-values for African children. Commonly used eGFR equations were applied in this population. Results: Normalization of SCr using Q-values for European descent children was effective in this cohort. The majority of African children (93.4%) have normalized SCr (SCr/Q) values within the reference interval (0.67–1.33) of children of European descent. The bedside-Schwartz equation was associated with significant age and sex dependency. However, the FAS-Age formula showed no sex and age dependency. The new CKiDU25 equation did not show a significant sex dependency. The recently introduced EKFC and LMR18 equations also showed no age and sex dependency, although the distribution of eGFR-values was not symmetrical. On the other hand, the FAS-Height and the Schwartz-Lyon equations showed significant sex dependency but no age dependency. Conclusions: The reference interval for SCr designed for European descent children can be applied to African children. Of all the equations studied, FAS-Age performed best and is most suitable because no height measurements are required. Establishment of specific Q-values for the widespread Jaffe-measured creatinine in Africa can further broaden applicability. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: