| Autor: |
Sasi, Pooja, C., Sumithra N. Unni, P. P., Sajitha Krishnan, Ravindran, Greeshma C. |
| Předmět: |
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| Zdroj: |
Medica Innovatica; Jan-Jun2024, Vol. 13 Issue 1, p43-48, 6p |
| Abstrakt: |
Background: Monoclonal gammopathies (MG) are a spectrum of diseases, which if diagnosed early can improve the disease prognosis. Serum Protein Electrophoresis (SPE) was the preferred screening test for MG, but the low sensitivity of the same emphasizes the necessity of going for more sensitive and accurate tests. SPE is complemented with tests like serum Free Light Chain assay (sFLC), Serum Immunofixation Electrophoresis (sIFE) and Serum Immunosubtraction Electrophoresis (sISE). Aim: Our aim was to find out the utility of each of these tests in diagnosing MG and propose a panel of tests for the diagnosis of MGs Material and methods: 30 patients with features of MG were recruited and SPE, sFLC, sIFE and sISE were performed. Results: Accuracy of sIFE with respect to sISE was 100% and accuracy of sFLC with respect to SPE came to be 90%. SPE, sFLC and sIFE panel and SPE, sFLC and sISE panel were able to detect all cases. Combination of SPE + sFLC + sIFE and SPE + sFLC + sISE tests were able to detect all 24 cases of MG and found to be efficient than any of these tests performed alone. Discussion: The diagnostic accuracy of sIFE and sISEin MM patients was compared and was found to be statistically insignificant thus proving that both tests contribute equally for the diagnosis of MM. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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