| Abstrakt: |
Parkinson disease (PD) is a neurodegenerative movement disorder. Beginning with Braak's theory that hypothesized a connection between gut, inflammation, and substantia nigra degeneration, many studies were made to put a link between inflammatory bowel disease and P D. We studied several patients with advanced PD, submitted in our Neurology Center, between July and September 2022 for initiation of device aided therapy with intestinal gel that fulfilled the admission criteria. We took under consideration the demographic data, UPDRS motor part III, ADL and IADL scales at day 1, after discharge and after 3 months. We provided biological analysis for D-Dimers, Fibrinogen, C Reactive Protein, ESR, and we compared the values from the 1st day of hospitalization and after 3 months; fecal samples were collected to evaluate the presence and the levels of fecal calprotectin (FC). In more than 60% of the cases, fecal calprotectin was higher than 100 ug/g (5 times normal), 80% more than 400, 20% more than 1000 ug/g, associating with modified inflammatory marks and clinical evaluation scores with no significant improvement in motor abilities in 3 months after discharge. In only 2 cases where calprotectin was below 22, there was a positive evolution in UPDRS motor part III score from 52 to 36 and from 29 to 21(from day 1 and after 3 months), alongside with 2 points in ADL, IADL scales. Inflammation biomarkers and fecal calprotectin in high ranges seem to associate difficulties in obtaining a good therapeutical response in advanced PD stages. [ABSTRACT FROM AUTHOR] |
