| Autor: |
Yu, Yeuni, Lee, Byunghyuk, Shin, Kihyuk, Kim, Kihun, Lee, Hyun Jung, Shin, Jun‐Oh, Lee, Jungsoo, Kim, Hoon‐Soo, Kim, Byung‐Soo, Kim, Moon‐Bum, Kim, Yun Hak, Ko, Hyun‐Chang |
| Předmět: |
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| Zdroj: |
Journal of the European Academy of Dermatology & Venereology; Sep2024, Vol. 38 Issue 9, p1776-1782, 7p |
| Abstrakt: |
Background: Lichen striatus (LS) is an acquired skin disorder with a linear pattern along Blaschko's lines. It commonly occurs in childhood, and the lesions spontaneously regress within several months. Objectives: Although up to 50% of LS cases exhibit hypopigmentation that can persist for several months to years, it is unknown why LS is associated with such a high incidence of hypopigmentation compared to other inflammatory skin diseases. Therefore, this study aimed to analyse the differences in the skin microbiome between LS patients with and without hypopigmentation. Methods: Differences in skin microbiome were analysed using whole genome sequencing of skin biopsies and subsequent bioinformatics analyses. Results: Some microbes commonly found in hypopigmented skin disorders, including Cutibacterium acnes, were more abundant in patients with LS showing hypopigmentation than in those not showing hypopigmentation. Conclusions: The skin microbiota may be involved in the development of hypopigmentation in LS and may be considered a treatment target to reduce LS duration and hypopigmentation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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