New Ewing Sarcoma Study Findings Have Been Published by a Researcher at University of Iowa [EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells].

Předmět:	EWING'S sarcoma RIBONUCLEOSIDE diphosphate reductase EXTRACELLULAR space CELL anatomy GENE expression
Zdroj:	Drug Week; 8/30/2024, p587-587, 1p
Abstrakt:	A recent study conducted at the University of Iowa has revealed new findings about Ewing sarcoma, a type of cancer. The study focused on the role of the activator protein-1 (AP-1) transcription factor family and the EWS-FLI1 oncogene in regulating the expression of extracellular-matrix proteins in Ewing sarcoma cells. The researchers found that AP-1 and EWS-FLI1 reciprocally regulate the expression of various extracellular-matrix proteins, which in turn affects cell morphology and phenotype. These findings provide valuable insights into the distinct features of Ewing sarcoma tumors and highlight a novel regulatory mechanism involving AP-1 and EWS-FLI1. [Extracted from the article]
Databáze:	Complementary Index
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