A feasibility randomized controlled trial of a community-level physical activity strategy for older adults with motoric cognitive risk syndrome.
| Autor: | Hernon, Shannon M., Singh, Yashi, Ward, Nathan, Kramer, Arthur F., Travison, Thomas G., Verghese, Joe, Fielding, Roger A., Kowaleski, Christopher, Reid, Kieran F. |
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| Předmět: |
COGNITION disorder risk factors
PATIENT education COMMUNITY health services SELF-evaluation PATIENT compliance PATIENT safety BEHAVIOR modification EXERCISE RESEARCH funding EDUCATIONAL outcomes STATISTICAL sampling PILOT projects BLIND experiment QUESTIONNAIRES RANDOMIZED controlled trials DESCRIPTIVE statistics COGNITION disorders QUALITY of life HEALTH behavior COMPARATIVE studies DATA analysis software MEDICAL screening PHYSICAL activity ACTIVE aging COMMUNITY-based social services OLD age |
| Zdroj: | Frontiers in Aging Neuroscience; 2024, p1-10, 10p |
| Abstrakt: | Themotoric cognitive risk syndrome (MCR) is a syndrome characterized by subjective memory complaints and slowwalking speeds that can identify older adults at increased risk for developing Alzheimer's disease or a related dementia (ADRD). To date, the feasibility of community-based physical activity (PA) programs for improving outcomes in MCR have yet to be examined. To address this knowledge gap, we conducted a translational randomized controlled trial (RCT) comparing 24-weeks of PA to a healthy aging education (HE) control intervention delivered within the infrastructure of an urban senior center in Greater Boston (clincaltrials.gov identifier: NCT03750682). An existing senior center employee was trained to administer the multimodal groupbased PA program that included moderate-intensity aerobic walking, strength, flexibility and balance training. A total of 79 older adults attended the senior center for a screening visit, of whom 29met the MCR criteria and 25 were randomized to PA orHE(meanage: 74.4±7years; BMI: 32.4±7kg/m2;85%female; 3MSE score: 92.4± 7; gait speed: 0.52 ± 0.1 m/s; SPPB score 4.8 ± 1.9). Due to the Covid-19 pandemic the study was stopped prematurely. Participants could successfully adhere to the study interventions (overall attendance rate: PA: 69% vs. HE:70% at study termination). Participants also successfully completed baseline and follow-up study assessments that included a computerized cognitive testing battery and objective tests of physical performance and functional exercise capacity. No study-related adverse events occurred. Notable trends for improved cognitive performance, gait speed and 6- minwalk distancewere exhibited in PA compared to HE.Our study provides important preliminary information to aid the design of larger-scale RCTs of PA that may help to preserve the independence of vulnerable older adults at high risk for ADRD in community-based settings. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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