| Autor: |
Hyo Jeong Kim, Kyung Won Kim, Young Su Joo, Junghwa Ryu, Hee-Yeon Jung, Kyung Hwan Jeong, Myung-Gyu Kim, Man Ki Ju, Seungyeup Han, Jong Soo Lee, Kyung Pyo Kang, Han Ro, Kyo Won Lee, Kyu Ha Huh, Myoung Soo Kim, Beom Seok Kim, Jaeseok Yang |
| Předmět: |
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| Zdroj: |
Transplant International; 2024, p1-10, 10p |
| Abstrakt: |
The optimal target blood pressure for kidney transplant (KT) patients remains unclear. We included 808 KT patients from the KNOW-KT as a discovery set, and 1,294 KT patients from the KOTRY as a validation set. The main exposures were baseline systolic blood pressure (SBP) at 1 year after KT and time-varying SBP. Patients were classified into five groups: SBP <110; 110-119; 120-129; 130-139; and =140 mmHg. SBP trajectories were classified into decreasing, stable, and increasing groups. Primary outcome was composite kidney outcome of =50% decrease in eGFR or death-censored graft loss. Compared with the 110-119 mmHg group, both the lowest (adjusted hazard ratio [aHR], 2.43) and the highest SBP (aHR, 2.25) were associated with a higher risk of composite kidney outcome. In time-varying model, also the lowest (aHR, 3.02) and the highest SBP (aHR, 3.60) were associated with a higher risk. In the trajectory model, an increasing SBP trajectory was associated with a higher risk than a stable SBP trajectory (aHR, 2.26). This associations were consistent in the validation set. In conclusion, SBP =140 mmHg and an increasing SBP trajectory were associated with a higher risk of allograft dysfunction and failure in KT patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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