| Autor: |
Ghadhban, Ahmed Talib, Ali Jassim, Marwa Mohammed, Mahmood, Majid Mohammed |
| Předmět: |
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| Zdroj: |
Dentistry 3000; 2023, Vol. 11 Issue 1, p1-5, 5p |
| Abstrakt: |
BACKGROUND: Both benign and harmful head and neck disorders have been associated with the Epstein-Barr virus (EBV). Many studies have connected EBV to oral squamous cell carcinoma (OSCC). Oral squamous cell carcinoma is the most prevalent type of cancer. Fresh 6ssue samples from pa6ents with OSCC were tested for the presence of Epstein-Barr virus. OBJECTIVE: To determine the frequency of EBV and IL10 expression in OSCC pa6ents. MATERIALS AND METHODS: FiLy individuals with OSCC and 25 with clinically healthy oral mucosa were studied. In situ hybridiza6on was used for the detec6on of EBV. Serum IL-10 levels were also evaluated in pa6ents and controls using a human IL-10 ELISA Kit. RESULTS: EBV was detected in 4 healthy pa6ents, 6 with moderately differen6ated OSCC, 10 with poorly differen6ated OSCC, and 19 with undifferen6ated OSCC. These differences were sta6s6cally significant (p<0.05). IL-10 expression was more common in OSCC diagnos6c groups than healthy controls, and the difference in blood IL-10 levels between pa6ents and controls was sta6s6cally significant (p<0.01). CONCLUSION: The prevalence of EBV in OSCC suggests its possible role in oral cavity malignancy. On the other hand, IL-10 is expressed at higher levels in OSCC biopsies; such elevated concentra6ons may promote viral spread. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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