| Abstrakt: |
Objective. To study associations between polymorphic variants of the SLC6A4 gene and depression in people aged 25–44 years old in Novosibirsk. Materials and methods. The study was performed in 2013–2016 and included 403 men (mean age 34 ± 0.4 years, response rate 71%) and 531 women (mean age 35 ± 0.4 years, response rate 72%) from an open population of residents aged 25–44 years in the Oktyabrskii district of Novosibirsk. Depression was assessed using the MONICA-MOPSY psychosocial questionnaire. The study polymorphisms of the SLC6A4 gene were genotyped using the PCR-RFLP method. Results. Depression was present in 12.8% of people aged 25–44 years (8.9% in the male population and 15.8% in the female population); moderate levels of depression occurred in 24.5% of the population (21.3% of men and 26.9% of women) (χ2 = 17.071, df = 2, p < 0.001). The most common genotype of the SLC6A4 gene in people aged 25–44 years in Novosibirsk was SLA (43.3%), followed by LALA (26.4%) and then SS (17.8%); less common genotypes in people aged 25–44 years were LALG (6.9%), SLG (4.4%), and LGLG (1.4%). Carriage of the SLA genotype (52.5% and 62.9%) increased the chance of developing both an moderate level of depression, by a factor of 2.4 (95% CI 1.278–4.355), and depression in general, by a factor of 1.9 (95% CI 1.142–3.271), as compared with carriers of the LALA genotype (31.9% and 46.7%), (χ2 = 7.674, df = 1, p < 0.01 and χ2 = 6.095, df = 1, p < 0.05). Carriers of the LALG genotype (57.9%) also had a higher chance of developing a moderate level of depression (OR = 2.929 (95% CI 1.039–8.261)) than carriers of the LALA genotype (31.9%) (χ2 = 4.326, df = 1, p < 0.05) (p < 0.05). Conclusions. Associations between polymorphic variants of the SLC6A4 gene and depression were found. [ABSTRACT FROM AUTHOR] |
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